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More Health News + Info In another study, a single four hundred mg IM injection of medroxyprogesterone was in comparison with venlafaxine 75 provera mg/day PO. Hot flash scores had been reduced by 79% in the medroxyprogesterone arm in comparison with fifty five% within the venlafaxine arm after 6 weeks (p less than 0.0001). In addition, significantly extra patients receiving medroxyprogesterone had a lower in sizzling flashes by 50% in comparison with baseline (seventy four% for medroxyprogesterone vs. forty six% for venlafaxine, p lower than 0.0001). The route and dosage of the drug determine pharmacologic results. The mode of action of medroxyprogesterone as palliative remedy in opposition to sure cancers has not been determined. Medroxyprogesterone contraceptive injections could provera also be used safely throughout breast-feeding. Detectable quantities of drug have been identified within the milk of moms receiving contraceptive injections of medroxyprogesterone. When estrogens are utilized in mixture with progestins, such therapy often is known as hormone substitute remedy or postmenopausal alternative therapy.When Lunelle is used for the prevention of conception in ladies, the same old dosage of medroxyprogesterone acetate is 25 mg (in fixed combination with 5 mg of estradiol cypionate per 0.5 mL) IM monthly.If HRT is used, it provera should be prescribed within the lowest efficient dosage and for the shortest duration consistent with therapy goals and risks for the individual ladies.Medroxyprogesterone acetate is used orally to cut back the incidence of endometrial hyperplasia and the attendant risk of endometrial carcinoma in postmenopausal ladies receiving estrogen substitute remedy. provera Although the drug shouldn't be used throughout pregnancy, there seems to be little or no increased danger of delivery defects in women who've inadvertently been uncovered to medroxyprogesterone acetate contraceptive injections in early being pregnant. Newborns exposed to medroxyprogesterone acetate in-utero and followed to adolescence confirmed no evidence of any antagonistic results on their health including their physical, mental, sexual or social development. Be alert to the potential for an ectopic pregnancy amongst women utilizing medroxyprogesterone contraceptive injections who complain of severe stomach pain or become pregnant throughout use. Medroxyprogesterone contraceptive injections shouldn't be used if there is a history of ectopic being pregnant or in diagnostic checks for pregnancy.