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Does metformin build up in your system? The kidneys process and clear the drug out of your system via urine. If your kidneys are not functioning properly, metformin can build up in your system and cause a condition called lactic acidosis. Lactic acidosis is when there is a dangerous amount of lactic acid in the body.



Is metformin safe to take long term? Generally, if you are prescribed metformin, you will be on it long term. That could be many decades, unless you experience complications or changes to your health that require you to stop taking it. However, metformin does have some side effects, and patients often have questions about the safety of long - term use.



What is a dangerously high blood sugar? If your blood sugar level tops 600 milligrams per deciliter (mg/dL), or 33.3 millimoles per liter (mmol/L), the condition is called diabetic hyperosmolar syndrome. Severely high blood sugar turns your blood thick and syrupy. Left untreated, this can lead to life-threatening dehydration and a diabetic coma.



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